thieno[3,2-b]pyridine-2-sulfonic acid [1-(1-amino-isoquinolin-7-ylmethyl)-2-oxo-pyrrolidin-3-yl]-amide

This compound is an experimental small molecule inhibitor with a unique aromatic polycyclic structure that includes an isoquinoline moiety fused to a pyridine ring and features a sulfonic acid group and an amide-linked pyrrolidinone. It was designed as part of research into orally active benzamidine isosteres for the inhibition of coagulation factor X (fXa), aiming to improve cell permeability and oral bioavailability compared to traditional benzamidines. The most potent analogs in this series demonstrated high selectivity for factor X over other serine proteases. There are no approved indications or clinical trials beyond preclinical/experimental stages[1][4][5].

Other names

thieno[3,2-b]pyridine derivative (as a class reference)